High impact journal for an interesting study that is admittedly largely out of my area of expertise. The limitation of it being done in animal models, is of course, noted, but also expected. The question I would ask is how well the underlying background research makes this outcome expected.
You joke, but rodents make great pets, because they are very social and have a range of personalities, but most only live a few years. I knew someone with a pet retired lab rat, and it lived much longer than the average fancy rat, but even then, it didn't even live half as long as the average cat or dog.
If we could breed or treat rodents to live longer, we could keep low-resource pets without as much loss.
> Therefore, this study examined the effects of late middle-aged (18-month-old) male and female C57BL6/J mice receiving two intranasal doses of hiPSC-NSC-EVs on neuroinflammaging in the hippocampus at 20.5 months of age.
The link to the actual paper was appreciated.
The context of whether findings will generalize outside of mouse models can depend a lot on specifics of the problem.
"Reverse brain aging", sure, in the same sense that taking Vitamin C reverses aging.
The nasal spray reduced markers of inflammation in hippocampal microglial cells.
A lot of things reduce inflammation. That is not "reversing ageing".
Of course, "reduces inflammation" doesn't headline very well...
The article is also heavily ai generated, I call bs on every single bit
>>The article is also heavily ai generated
can you please share your methodology for detecting ai please?
I thought the url said temu at first.
Kinda surprised A&M’s letting them use AI to write these things
c'mon you guys, chill. this is not a vaccine.
High impact journal for an interesting study that is admittedly largely out of my area of expertise. The limitation of it being done in animal models, is of course, noted, but also expected. The question I would ask is how well the underlying background research makes this outcome expected.
That's exactly what I want: immortal mice!
You joke, but rodents make great pets, because they are very social and have a range of personalities, but most only live a few years. I knew someone with a pet retired lab rat, and it lived much longer than the average fancy rat, but even then, it didn't even live half as long as the average cat or dog.
If we could breed or treat rodents to live longer, we could keep low-resource pets without as much loss.
That's a surprisingly underused plot for a sci Fi horror film.
Considering the grand total of experiments we've ran on the little guys, I'm kinda surprised we haven't bred Mousezilla yet
How soon until biohackers try this on themselves?
I take N-acetylcysteine and it helps with brain fog also! Plus it reduces stress and irritability.
Ugh, I thought we were done with the Boomers....looks like they're gonna hang on.
When can I snort this?
Prepare a line for me also please
Grab me a bag while your there.
[delayed]
Flowers for Algernon’s Brain
...in mice.
> Therefore, this study examined the effects of late middle-aged (18-month-old) male and female C57BL6/J mice receiving two intranasal doses of hiPSC-NSC-EVs on neuroinflammaging in the hippocampus at 20.5 months of age.
— https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...
That PR piece was brutal to navigate. Undoubtedly punched up by AI, it took far too long to even understand what the treatment entailed.
To be fair though, I think we owe the mice a positive research outcome.
“Congratulations, you get improved brain function while we continue to run other experiments on you!”
You can now experience both physical pain and existential dread!
“There will be cake!”
The link to the actual paper was appreciated. The context of whether findings will generalize outside of mouse models can depend a lot on specifics of the problem.
Mice get all the cool shit first
they get all the worst and most inane tortures too
Then they get murdered...
I even seen a mouse on youtube with it's own tiny EV sports car driving about!
I read a book about a mouse with a motorcycle (https://www.goodreads.com/en/book/show/232109.The_Mouse_and_...) and a different book about a mouse-like child with sailboat. (https://www.goodreads.com/en/book/show/138959.Stuart_Little).
M. Night Shyamalan wrote a screenplay about the latter book, and it was made into a popular movie.